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Disclosures: Kris Kowdley: Nothing to Disclose, Maged Peter Ghali: Mirum pharmaceuticals: Grant/Research Support, Gilead Sciences: Grant/Research Support, Novo Nordisk: Grant/Research Support, Pfizer: Grant/Research Support, Madrigal: Grant/Research Support, Alan Bonder: GSK: Grant/Research Support, Mirium: Grant/Research Support, Gilead: Grant/Research Support, Ipsen: Grant/Research Support, Cymabay: Grant/Research Support, Intercept: Grant/Research Support, Intercept: Consultant, GSK: Consultant, Ipsen: Consultant, Chemobab: Grant/Research Support, Alnylam: Consultant, Thirammune: Consultant, Stuart Gordon: Nothing to Disclose, Robert Rahimi: Salix: Grant/Research Support, Mallinckrodt: Grant/Research Support, Cory Kostrub: Mirum Pharmaceuticals: Employee, Tiago Nunes: Nothing to Disclose, Josephine Shelton: Nothing to Disclose, Will Garner: Mirum Pharmaceuticals: Employee, Mirum Pharmaceuticals: Stock - publicly traded company, Pamela Vig: Nothing to Disclose, Naim Alkhouri: Madrigal: Grant/Research Support, Madrigal: Speaking and Teaching, Novo Nordisk: Consulting, Novo Nordisk: Grant/Research Support, Gilead: Grant/Research Support, Corcept: Grant/Research Support, Boehringer Ingelheim: Grant/Research Support, Echosens: Speaking and Teaching, Perspectum: Consultant, Cima: Consultant, Fibronostics: Consultant, 89Bio: Grant/Research Support, Inventiva: Grant/Research Support, Merck: Grant/Research Support, Pfizer: Grant/Research Support, Ipsen: Speaking and Teaching, Intercept: Speaking and Teaching, Madrigal: Consulting, Research Funding, Novo Nordisk: Consulting, Research Funding, Inventiva: Research Funding, Boehringer Ingelheim: Consulting, Research Funding, Corcept: Research Funding, Ipsen: Consulting, Research Funding, Gliead: Consulting, Research Funding, Speaking, Perspectum: Consulting, Research Funding, Cima: Advisor, 89Bio: Consulting, Research Funding, Akero: Grant/Research Support 2418 CORRELATION BETWEEN THE PHARMACOKINETICS OF THE OPIOID ANTAGONIST NALMEFENE AND PRURITUS RELIEF IN PATIENTS WITH CHOLESTATIC PRURITUS Nir Barak 1 Sireesh Appajosyla 1 , 1 Tharimmune Inc Background: Previous studies showed the potential of opioid antagonists to relieve itch in patients with cholestatic pruritus